一、产品名称

Anti-Digoxin Antibody (26G10) (RGK23001)

二、产品描述

Digoxin是Na⁺/K⁺-ATP酶的强效抑制剂，专门针对从毛地黄植物提取的一种心脏糖苷。此药物常用于治疗心房颤动、心房扑动及心力衰竭等心血管疾病，其机制为抑制Na⁺/K⁺-ATP酶。尽管其治疗效果显著，但Digoxin的治疗范围较窄，并伴随一定的毒副作用。由26-10克隆制备的Fab片段具有中和作用，在洋地黄过量的情况下可用作解毒剂。此外，该抗体还可用于测量药物的血清水平，为治疗提供指导，并在抗体与抗原相互作用动力学的研究中具有重要意义。

三、产品详情

• 名称：Anti-Digoxin Antibody (26G10) (RGK23001)
• 别名：Digoxin, DGX, CAS:, digoxinum, 12β-hydroxydigitoxin, ChEBI:4551, 26-10#, 26G10
• 货号：RGK23001
• 宿主：Mouse
• 同种型：IgG2a, kappa
• 克隆类型：Monoclonal
• 靶标：Digoxin, DGX, CAS:, digoxinum, 12β-hydroxydigitoxin, ChEBI:4551, 26-10#, 26G10
• 浓度：34 mg/ml
• 内毒素水平：请联系实验室获取该信息
• 纯度：95%，依据SDS-PAGE测定
• 纯化方式：通过Protein A/G从细胞培养上清液中纯化
• 克隆号：26G10
• 应用：CLIA, DB, ELISA, IP, RIA, WB
• 状态：液态
• 保存溶液：001M PBS, pH 7.4
• 稳定性和存储：使用手动解冻冰箱，避免反复冻融。短期存储于4°C（1-2周），长期存储于-20°C（12个月），-80°C（长期）

四、参考文献

• Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis PMID: 34853001
• Role of Digoxin in Atrial Fibrillation PMID: 27067743
• Digoxin protects against intervertebral disc degeneration via TNF/NF-kappaB and LRP4 signaling PMID: 37790932
• Digoxin--issues and controversies PMID: 3510096
• Digoxin PMID: 1120872
• Digoxin--a redundant drug in congestive cardiac failure PMID: 2488085
• Digoxin toxicity in the aged: Characterizing and avoiding the problem PMID: 1794026
• Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia PMID: 35064518
• Digoxin PMID: 3185769
• A baby with digoxin toxicity PMID: 25944069
• An nomogram for digoxin therapy PMID: 4600984
• Clinical pharmacokinetics of digoxin 1980 PMID: 6988136
• Digoxin therapy: textbooks, theory and practice PMID: 22216507
• Digoxin bioavailability PMID: 82124
• A perspective on re-evaluating digoxin's role in the current management of patients with chronic systolic heart failure: targeting serum concentration to reduce hospitalization and improves safety profile PMID: 24574198
• Digoxin in the 1980s PMID: 3309595
• Computer-assisted digoxin therapy PMID: 4763409
• Quinidine-digoxin interaction PMID: 7436201
• Clinical pharmacology of digoxin PMID: 4558886
• How to digitalize and maintain optimal digoxin levels in congestive heart failure PMID: 2488083
• Digoxin: placental transfer, effects on the fetus, and therapeutic use in the newborn PMID: 1102216
• Digoxin in heart failure PMID: 2569093
• Serum digoxin concentrations in atrial fibrillation: a review PMID: 7049644
• Digoxin therapeutics: straightening out the facts PMID: 1513197
• The rational pharmacology of digoxin PMID: 1389200
• Population Pharmacokinetic Studies of Digoxin in Adult Patients: A Systematic Review PMID: 33616855
• Digoxin Use and Subsequent Outcomes Among Patients in a Contemporary Atrial Fibrillation Cohort PMID: 26112191
• Understanding digoxin use in the elderly patient PMID: 2253445
• Pharmacokinetics of digoxin in the rat PMID: 3407
• Is there an expanded role for digoxin in patients with heart failure and sinus rhythm? A protagonist viewpoint PMID: 9220052
• Digoxin metabolism in patients PMID: 666466
• Serum digoxin test in perspective PMID: 912635
• Bioavailability of digoxin PMID: 4113330

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